5-HT6 receptor

HTR6
Identifiers
Aliases	HTR6, 5-HT6, 5-HT6R, 5-HT6 receptor, 5-hydroxytryptamine receptor 6
External IDs	MGI: 1196627 HomoloGene: 673 GeneCards: HTR6
Targeted by Drug
EMD-386088, way-181187, 5-carboxamidotryptamine, pathogen, 5-methoxytryptamine, bromocriptine, dimethyltryptamine, EMDT, ergotamine, lysergide, ru-24969, 1-(3-trifluoromethylphenyl)piperazine, xanomeline, brl-15572, donitriptan, E-6801, gr-127935, lisuride, amitriptyline, amoxapine, cerlapirdine, cyproheptadine, duloxetine, iloperidone, mesulergine, metergoline, metitepine, methysergide, mianserin, risperidone, ritanserin, Ro 04-6790, SB258585, SB 271046, SB357134, SB399885, sumatriptan, tiospirone, vortioxetine, chlorpromazine, clozapine, fluperlapine, fluphenazine, loxapine, olanzapine, perphenazine, thioridazine, zotepine, idalopirdine
Gene ontology Molecular function • histamine receptor activity • protein binding • G-protein coupled receptor activity • signal transducer activity • neurotransmitter receptor activity • G-protein coupled serotonin receptor activity Cellular component • integral component of membrane • plasma membrane • integral component of plasma membrane • cilium • membrane Biological process • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • G-protein coupled receptor signaling pathway • cerebral cortex cell migration • positive regulation of TOR signaling • signal transduction • chemical synaptic transmission • G-protein coupled serotonin receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3362	15565
Ensembl	ENSG00000158748	ENSMUSG00000028747
UniProt	P50406	Q9R1C8
RefSeq (mRNA)	NM_000871	NM_021358
RefSeq (protein)	NP_000862	NP_067333.1 NP_067333
Location (UCSC)	Chr 1: 19.67 – 19.68 Mb	Chr 4: 139.06 – 139.08 Mb
PubMed search

3362

15565

ENSG00000158748

ENSMUSG00000028747

P50406

Q9R1C8

NM_000871

NM_021358

NP_000862

NP_067333.1
NP_067333

The 5-HT₆ receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). It is a G protein-coupled receptor (GPCR) that is coupled to G_s and mediates excitatory neurotransmission.HTR6 denotes the human gene encoding for the receptor.

The 5-HT₆ receptor is expressed almost exclusively in the brain. It is distributed in various areas including, but not limited to, the olfactory tubercle, cerebral cortex (frontal and entorhinal regions), nucleus accumbens, striatum, caudate nucleus, hippocampus, and the molecular layer of the cerebellum. Based on its abundance in extrapyramidal, limbic, and cortical regions it can be suggested that the 5-HT₆ receptor plays a role in functions like motor control, emotionality, cognition, and memory.

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Wikipedia