5-lipoxygenase

ALOX5

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3O8Y, 3V92, 3V98, 3V99

Identifiers

Aliases

ALOX5, Alox5, 5-LO, 5-LOX, 5LO, 5LX, AI850497, F730011J02, 5LPG, LOG5, arachidonate 5-lipoxygenase

External IDs

MGI: 87999 HomoloGene: 561 GeneCards: ALOX5

Targeted by Drug

zileuton

Gene ontology
Molecular function	• iron ion binding • arachidonate 5-lipoxygenase activity • dioxygenase activity • metal ion binding • protein binding • oxidoreductase activity • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Cellular component	• cytoplasm • cytosol • nuclear membrane • membrane • nuclear matrix • nuclear envelope lumen • nucleus • extracellular region • extracellular space • nuclear envelope • nucleoplasm • secretory granule lumen • ficolin-1-rich granule lumen
Biological process	• leukotriene metabolic process • leukotriene production involved in inflammatory response • leukotriene biosynthetic process • inflammatory response • lipoxin metabolic process • oxidation-reduction process • lipoxygenase pathway • neutrophil degranulation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


240


11689

Ensembl


n/a


ENSMUSG00000025701

UniProt


P09917


P48999

RefSeq (mRNA)


NM_000698 NM_001256153 NM_001256154 NM_001320861 NM_001320862


NM_009662

RefSeq (protein)


NP_000689 NP_001243082 NP_001243083 NP_001307790 NP_001307791


NP_033792.1 NP_033792

Location (UCSC)

Chr 10: 45.37 – 45.45 Mb

Chr 6: 116.41 – 116.46 Mb

PubMed search

arachidonate 5-lipoxygenase

Identifiers

Databases

PDB structures

AmiGO / EGO

Search
PMC	articles
PubMed	articles
NCBI	proteins

Search
PMC	articles
PubMed	articles
NCBI	proteins

3O8Y, 3V92, 3V98, 3V99

n/a

NM_000698
NM_001256153
NM_001256154
NM_001320861
NM_001320862

NM_009662

NP_000689
NP_001243082
NP_001243083
NP_001307790
NP_001307791

NP_033792.1
NP_033792

...
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