ARHGEF2

ARHGEF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5EFX
Identifiers
Aliases	ARHGEF2, GEF, GEF-H1, GEFH1, LFP40, P40, Rho/Rac guanine nucleotide exchange factor 2, NEDMHM
External IDs	MGI: 103264 HomoloGene: 3468 GeneCards: ARHGEF2
Gene ontology Molecular function • Rac guanyl-nucleotide exchange factor activity • Rac GTPase binding • microtubule binding • zinc ion binding • transcription factor binding • metal ion binding • protein binding • Rho GTPase binding • Rho guanyl-nucleotide exchange factor activity • guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • vesicle • cytosol • Golgi apparatus • cell projection • membrane • focal adhesion • bicellular tight junction • spindle • plasma membrane • protein complex • dendritic shaft • ruffle membrane • cell junction • neuronal cell body • microtubule • cytoskeleton • cytoplasmic vesicle • podosome • postsynaptic density of dendrite Biological process • intracellular signal transduction • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress • negative regulation of necroptotic process • actin filament organization • immune system process • negative regulation of neurogenesis • cellular response to tumor necrosis factor • cell division • cellular response to muramyl dipeptide • cellular hyperosmotic response • negative regulation of microtubule depolymerization • regulation of cell proliferation • positive regulation of NF-kappaB transcription factor activity • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • cell morphogenesis • establishment of mitotic spindle orientation • positive regulation of interleukin-6 production • positive regulation of tumor necrosis factor production • positive regulation of apoptotic process • positive regulation of peptidyl-tyrosine phosphorylation • cell cycle • regulation of Rho protein signal transduction • intracellular protein transport • innate immune response • regulation of small GTPase mediated signal transduction • positive regulation of transcription from RNA polymerase II promoter • positive regulation of GTPase activity • negative regulation of podosome assembly Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9181	16800
Ensembl	ENSG00000116584	ENSMUSG00000028059
UniProt	Q92974	Q60875
RefSeq (mRNA)	NM_001162383 NM_001162384 NM_004723 NM_001350110 NM_001350111 NM_001350112	NM_001198911 NM_001198912 NM_001198913 NM_008487
RefSeq (protein)	NP_001155855 NP_001155856 NP_004714 NP_001337039 NP_001337040 NP_001337041	NP_001185840 NP_001185841 NP_001185842 NP_032513
Location (UCSC)	Chr 1: 155.95 – 156.01 Mb	Chr 3: 88.61 – 88.65 Mb
PubMed search

5EFX

9181

16800

ENSG00000116584

ENSMUSG00000028059

Q92974

Q60875

NM_001350112

NM_001198911
NM_001198912
NM_001198913
NM_008487

NP_001337041

NP_001185840
NP_001185841
NP_001185842
NP_032513

Rho guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the ARHGEF2 gene.

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals.

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