ARID1B

ARID1B
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2CXY, 2EH9
Identifiers
Aliases	ARID1B, 6A3-5, BAF250B, BRIGHT, DAN15, ELD/OSA1, MRD12, OSA2, P250R, CSS1, AT-rich interaction domain 1B
External IDs	MGI: 1926129 HomoloGene: 32344 GeneCards: ARID1B
Gene ontology Molecular function • DNA binding • transcription coactivator activity • protein binding Cellular component • BAF-type complex • nBAF complex • SWI/SNF complex • nucleus • nucleoplasm • cytosol • plasma membrane Biological process • chromatin remodeling • regulation of transcription, DNA-templated • chromatin-mediated maintenance of transcription • transcription, DNA-templated • nervous system development • covalent chromatin modification • neuron-neuron synaptic transmission • dendritic spine development • dendritic cell dendrite assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57492	239985
Ensembl	ENSG00000049618	ENSMUSG00000069729
UniProt	Q8NFD5	n/a
RefSeq (mRNA)	NM_017519 NM_020732 NM_001346813	NM_001085355
RefSeq (protein)	NP_001333742 NP_059989 NP_065783	n/a
Location (UCSC)	Chr 6: 156.78 – 157.21 Mb	Chr 17: 4.99 – 5.35 Mb
PubMed search

2CXY, 2EH9

57492

239985

ENSG00000049618

ENSMUSG00000069729

Q8NFD5

n/a

NM_017519
NM_020732
NM_001346813

NM_001085355

NP_001333742
NP_059989
NP_065783

n/a

AT-rich interactive domain-containing protein 1B is a protein that in humans is encoded by the ARID1B gene. ARID1B is a component of the human SWI/SNF chromatin remodeling complex.

Germline mutations in ARID1B are associated with Coffin-Siris syndrome. Somatic mutations in ARID1B are associated with several cancer subtypes, suggesting that it is a tumor suppressor gene.

ARID1B has been shown to interact with SMARCA4 and SMARCA2.

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Wikipedia