Antiglucocorticoid

Antiglucocorticoid
Drug class
Mifepristone, an antiglucocorticoid that is used in the treatment of Cushing's syndrome.
Class identifiers
Synonyms	Glucocorticoid antagonist; Cortisol antagonist; Anticorticosteroid
Use	Cushing's syndrome, others
Biological target	Glucocorticoid receptor
Chemical class	Steroids

An antiglucocorticoid is a drug which reduces glucocorticoid activity in the body. They include direct glucocorticoid receptor antagonists such as mifepristone and synthesis inhibitors such as metyrapone, , and aminoglutethimide. They are used to treat Cushing's syndrome.

Antiglucocorticoids could be effective antidepressants for a subset of specific mood disorders, but their use is limited by side effects.