CKM (gene)

CKM
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1I0E
Identifiers
Aliases	CKM, CKMM, M-CK, creatine kinase, M-type
External IDs	MGI: 88413 HomoloGene: 20432 GeneCards: CKM
Gene ontology Molecular function • transferase activity • creatine kinase activity • transferase activity, transferring phosphorus-containing groups • nucleotide binding • catalytic activity • protein binding • ATP binding • kinase activity Cellular component • cytoplasm • cytosol Biological process • creatine metabolic process • phosphocreatine biosynthetic process • phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1158	12715
Ensembl	ENSG00000104879	ENSMUSG00000030399
UniProt	P06732	P07310
RefSeq (mRNA)	NM_001824	NM_007710
RefSeq (protein)	NP_001815	NP_031736.1 NP_031736
Location (UCSC)	Chr 19: 45.31 – 45.32 Mb	Chr 7: 19.4 – 19.42 Mb
PubMed search

1I0E

1158

12715

ENSG00000104879

ENSMUSG00000030399

P06732

P07310

NM_001824

NM_007710

NP_001815

NP_031736.1
NP_031736

Creatine kinase, muscle also known as CKM is a creatine kinase that in humans is encoded by the CKM gene.

In the figure to the right, the crystal structure of the muscle-type M-CK monomer is shown. In vivo, two such monomers arrange symmetrically to form the active MM-CK enzyme.

The protein encoded by this gene is a cytoplasmic enzyme involved in cellular energy homeostasis. The encoded protein reversibly catalyzes the transfer of "energy-rich" phosphate between ATP and creatine and between phospho-creatine and ADP. Its functional entity is a MM-CK homodimer in striated (sarcomeric) skeletal and cardiac muscle.

In heart, in addition to the MM-CK homodimer, also the heterodimer MB-CK consisting of one muscle (M-CK) and one brain-type (B-CK) subunit is expressed. The latter may be an important serum marker for myocardial infarction, if released from damaged myocardial cells into the blood where it can be detected by clinical chemistry.

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Wikipedia