COL12A1

COL12A1
Identifiers
Aliases	COL12A1, BA209D8.1, COL12A1L, DJ234P15.1, BTHLM2, UCMD2, collagen type XII alpha 1, collagen type XII alpha 1 chain
External IDs	MGI: 88448 HomoloGene: 3217 GeneCards: COL12A1
Gene ontology Molecular function • extracellular matrix structural constituent conferring tensile strength Cellular component • extracellular vesicle • extracellular region • collagen type XII trimer • proteinaceous extracellular matrix • collagen trimer • endoplasmic reticulum lumen • extracellular exosome • extracellular space • extracellular matrix Biological process • collagen catabolic process • skeletal system development • cell adhesion • endodermal cell differentiation • collagen fibril organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1303	12816
Ensembl	ENSG00000111799	ENSMUSG00000032332
UniProt	Q99715	Q60847
RefSeq (mRNA)	NM_004370 NM_080645	NM_001290308 NM_007730
RefSeq (protein)	NP_004361 NP_542376	NP_001277237
Location (UCSC)	Chr 6: 75.08 – 75.21 Mb	Chr 9: 79.6 – 79.72 Mb
PubMed search

1303

12816

ENSG00000111799

ENSMUSG00000032332

Q99715

Q60847

NM_004370
NM_080645

NM_001290308
NM_007730

NP_004361
NP_542376

NP_001277237

Collagen alpha-1(XII) chain is a protein that in humans is encoded by the COL12A1 gene.

This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to modify the interactions between collagen I fibrils and the surrounding matrix. Alternatively spliced transcript variants encoding different isoforms have been identified.

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