CP-122,288

CP-122,288
Identifiers

IUPAC name N-methyl-1-[3-([(2R)-1-methylpyrrolidin-2-yl]methyl)-1H-indol-5-yl]methanesulfonamide
CAS Number	143321-74-8
PubChem CID	132552
IUPHAR/BPS	110
ChemSpider	117032
Chemical and physical data
Formula	C₁₆H₂₃N₃O₂S
Molar mass	321.437 g/mol
3D model (JSmol)	Interactive image
SMILES CNS(=O)(=O)Cc1ccc2c(c1)c(c[nH]2)C[C@H]3CCCN3C
InChI InChI=1S/C16H23N3O2S/c1-17-22(20,21)11-12-5-6-16-15(8-12)13(10-18-16)9-14-4-3-7-19(14)2/h5-6,8,10,14,17-18H,3-4,7,9,11H2,1-2H3/t14-/m1/s1 Key:BWQZTHPHLITOOZ-CQSZACIVSA-N

CP-122,288 is a drug which acts as a potent and selective agonist for the 5-HT_1B, 5-HT_1D and 5-HT_1F serotonin receptor subtypes. It is a derivative of the migraine medication sumatriptan, but while CP-122,288 is 40,000 times more potent than sumatriptan as an inhibitor of neurogenic inflammation and plasma protein extravasation, it is only twice as potent as a constrictor of blood vessels. In human trials, CP-122,288 was not found to be effective as a treatment for migraine, but its selectivity for neurogenic anti-inflammatory action over vasoconstriction has made it useful for research into the underlying causes of migraine.

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