Cav1.2

CACNA1C

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1T0J, 2BE6, 2F3Z, 2LQC, 3G43, 3OXQ

Identifiers

Aliases

CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1, CaV1.2, LQT8, TS, calcium voltage-gated channel subunit alpha1 C

External IDs

OMIM: 114205 MGI: 103013 HomoloGene: 55484 GeneCards: CACNA1C

Genetically Related Diseases

schizophrenia, bipolar disorder, major depressive disorder

Targeted by Drug

diltiazem, mibefradil, verapamil, nifedipine, nisoldipine

Gene ontology
Molecular function	• calcium channel activity • metal ion binding • voltage-gated ion channel activity • calmodulin binding • ion channel activity • protein binding • alpha-actinin binding • voltage-gated calcium channel activity • voltage-gated calcium channel activity involved in cardiac muscle cell action potential • high voltage-gated calcium channel activity • voltage-gated calcium channel activity involved in AV node cell action potential
Cellular component	• cytoplasm • voltage-gated calcium channel complex • integral component of membrane • membrane • postsynaptic density • plasma membrane • Z disc • L-type voltage-gated calcium channel complex
Biological process	• calcium ion transport into cytosol • regulation of insulin secretion • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion • positive regulation of cytosolic calcium ion concentration • cell communication by electrical coupling involved in cardiac conduction • regulation of ion transmembrane transport • ion transport • calcium-mediated signaling using extracellular calcium source • cardiac conduction • transmembrane transport • transport • calcium ion transport • regulation of ventricular cardiac muscle cell action potential • embryonic forelimb morphogenesis • immune system development • regulation of heart rate by cardiac conduction • membrane depolarization during cardiac muscle cell action potential • calcium ion transmembrane transport via high voltage-gated calcium channel • membrane depolarization during AV node cell action potential • heart development • membrane depolarization during atrial cardiac muscle cell action potential • cardiac muscle cell action potential involved in contraction • calcium ion transmembrane transport • camera-type eye development
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


775


12288

Ensembl


ENSG00000151067


ENSMUSG00000051331

UniProt


Q13936


Q01815

RefSeq (mRNA)

NM_000719 NM_001129827 NM_001129829 NM_001129830 NM_001129831
NM_001129832 NM_001129833 NM_001129834 NM_001129835 NM_001129836 NM_001129837 NM_001129838 NM_001129839 NM_001129840 NM_001129841 NM_001129842 NM_001129843 NM_001129844 NM_001129846 NM_001167623 NM_001167624 NM_001167625 NM_199460

NM_001159533 NM_001159534 NM_001159535 NM_001255997 NM_001255998
NM_001255999 NM_001256000 NM_001256001 NM_001256002 NM_009781 NM_001290335

RefSeq (protein)

NP_000710 NP_001123299 NP_001123301 NP_001123302 NP_001123303
NP_001123304 NP_001123305 NP_001123306 NP_001123307 NP_001123308 NP_001123309 NP_001123310 NP_001123311 NP_001123312 NP_001123313 NP_001123314 NP_001123315 NP_001123316 NP_001123318 NP_001161095 NP_001161096 NP_001161097 NP_955630

NP_001153005.1 NP_001153005 NP_001153006 NP_001153007 NP_001242926
NP_001242927 NP_001242928 NP_001242929 NP_001242930 NP_001242931 NP_001277264 NP_033911

Location (UCSC)

Chr 12: 1.97 – 2.7 Mb

Chr 6: 118.59 – 119.2 Mb

PubMed search

1T0J, 2BE6, 2F3Z, 2LQC, 3G43, 3OXQ

NM_001129832
NM_001129833
NM_001129834
NM_001129835
NM_001129836
NM_001129837
NM_001129838
NM_001129839
NM_001129840
NM_001129841
NM_001129842
NM_001129843
NM_001129844
NM_001129846
NM_001167623
NM_001167624
NM_001167625
NM_199460

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