ChREBP

MLXIPL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GNT
Identifiers
Aliases	MLXIPL, CHREBP, MIO, MONDOB, WBSCR14, WS-bHLH, bHLHd14, MLX interacting protein like, MLX
External IDs	MGI: 1927999 HomoloGene: 32507 GeneCards: MLXIPL
Gene location (Human) Chr. Chromosome 7 (human) Band 7q11.23 Start 73,593,194 bp End 73,624,543 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 G2 Start 135,089,890 bp End 135,138,382 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • carbohydrate response element binding • DNA binding • protein dimerization activity • protein homodimerization activity • transcription factor activity, sequence-specific DNA binding • transcription factor binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein heterodimerization activity • RNA polymerase II transcription factor activity, sequence-specific DNA binding Cellular component • transcription factor complex • nucleoplasm • cell nucleus • cytoplasm • cytosol Biological process • intracellular signal transduction • positive regulation of lipid biosynthetic process • regulation of transcription, DNA-templated • glucose homeostasis • regulation of transcription from RNA polymerase II promoter • anatomical structure morphogenesis • negative regulation of transcription from RNA polymerase II promoter • positive regulation of fatty acid biosynthetic process • transcription, DNA-templated • negative regulation of cell cycle arrest • positive regulation of transcription, DNA-templated • fatty acid homeostasis • positive regulation of cell proliferation • negative regulation of peptidyl-serine phosphorylation • glucose mediated signaling pathway • negative regulation of oxidative phosphorylation • negative regulation of transcription, DNA-templated • positive regulation of glycolytic process • triglyceride homeostasis • positive regulation of transcription from RNA polymerase II promoter • cellular response to carbohydrate stimulus • energy homeostasis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51085	58805
Ensembl	ENSG00000009950	ENSMUSG00000005373
UniProt	Q9NP71	Q99MZ3
RefSeq (mRNA)	NM_032951 NM_032952 NM_032953 NM_032954 NM_032994	NM_021455 NM_001359237
RefSeq (protein)	NP_116569 NP_116570 NP_116571 NP_116572	NP_067430 NP_001346166
Location (UCSC)	Chr 7: 73.59 – 73.62 Mb	Chr 5: 135.09 – 135.14 Mb
PubMed search

4GNT

51085

58805

ENSG00000009950

ENSMUSG00000005373

Q9NP71

Q99MZ3

NM_032951
NM_032952
NM_032953
NM_032954
NM_032994

NM_021455
NM_001359237

NP_116569
NP_116570
NP_116571
NP_116572

NP_067430
NP_001346166

Carbohydrate-responsive element-binding protein (ChREBP) also known as MLX-interacting protein-like (MLXIPL) is a protein that in humans is encoded by the MLXIPL gene. The protein name derives from the protein's interaction with carbohydrate response element sequences of DNA.

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