Chordopoxvirinae
| Chordopoxvirinae | |
|---|---|
| Virus classification | |
| Group: | Group I (dsDNA) |
| Family: | Poxviridae |
| Subfamily: | Chordopoxvirinae |
| Genera | |
Chordopoxvirinae is a subfamily of viruses, in the family Poxviridae. Humans, vertebrates, and arthropods serve as natural hosts. There are currently 38 species in this subfamily, divided among 10 genera. Diseases associated with this subfamily include: Variola virus: smallpox.
Four genera in this subfamily contain species that infect humans: Molluscipoxvirus, Orthopoxvirus, Parapoxvirus and Yatapoxvirus.
The virions are generally enveloped though the intracellular mature virion form of the virus, which contains a different envelope, is also infectious. They vary in their shape depending upon the species but are generally shaped like a brick or as an oval form similar to a rounded brick because they are wrapped by the endoplasmic reticulum. The virion is exceptionally large, its size is around 200 nm in diameter and 300 nm in length and carries its genome in a single, linear, double-stranded segment of DNA. Genomes are linear, around 130-375kb in length.
Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell. Fusion with the plasma membrane to release the core into the host cytoplasm. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV). IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV)host receptors, which mediates endocytosis. Replication follows the DNA strand displacement model. DNA-templated transcription is the method of transcription. The virus exits the host cell by microtubular outwards viral transport, and existing in occlusion bodies after cell death and remaining infectious until finding another host. Humans, vertebrates, and arthropods serve as the natural host. Transmission routes are fomite, contact, and air borne particles.
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