DFFA

DFFA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IBX, 1IYR, 1KOY
Identifiers
Aliases	DFFA, DFF-45, DFF1, ICAD, DNA fragmentation factor subunit alpha
External IDs	MGI: 1196227 HomoloGene: 3240 GeneCards: DFFA
Gene ontology Molecular function • protein binding • protein domain specific binding • protein binding involved in protein folding • deoxyribonuclease inhibitor activity Cellular component • nuclear chromatin • cytosol • lipid particle • intracellular • nucleus • nucleoplasm • cytoplasm • plasma membrane Biological process • positive regulation of apoptotic process • negative regulation of execution phase of apoptosis • negative regulation of apoptotic DNA fragmentation • apoptotic DNA fragmentation • thymocyte apoptotic process • apoptotic process • negative regulation of deoxyribonuclease activity • chaperone-mediated protein folding Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1676	13347
Ensembl	ENSG00000160049	ENSMUSG00000028974
UniProt	O00273	O54786
RefSeq (mRNA)	NM_213566 NM_004401	NM_001025296 NM_010044
RefSeq (protein)	NP_004392 NP_998731 NP_998731.1	NP_001020467.1 NP_001020467 NP_034174
Location (UCSC)	Chr 1: 10.46 – 10.47 Mb	Chr 4: 149.1 – 149.12 Mb
PubMed search

DNA Fragmentation factor 45kDa, C terminal domain
nmr structure of dff-c domain
Identifiers
Symbol	DFF-C
Pfam	PF09033
InterPro	IPR015121
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

1IBX, 1IYR, 1KOY

1676

13347

ENSG00000160049

ENSMUSG00000028974

O00273

O54786

NM_213566
NM_004401

NM_001025296
NM_010044

NP_004392
NP_998731
NP_998731.1

NP_001020467.1
NP_001020467
NP_034174

DNA fragmentation factor subunit alpha (DFFA), also known as Inhibitor of caspase-activated DNase (ICAD), is a protein that in humans is encoded by the DFFA gene.