Dihydrofolate reductase

Dihydrofolate reductase
Crystal structure of chicken liver dihydrofolate reductase. PDB entry 8dfr
Identifiers
EC number	1.5.1.3
CAS number	9002-03-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

R67 dihydrofolate reductase
High-resolution structure of a plasmid-encoded dihydrofolate reductase from E.coli. PDB entry 2gqv
Identifiers
Symbol	DHFR_2
Pfam	PF06442
InterPro	IPR009159
SCOP	1vif
SUPERFAMILY	1vif
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

DHFR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BOZ, 1DHF, 1DLR, 1DLS, 1DRF, 1HFP, 1HFQ, 1HFR, 1KMS, 1KMV, 1MVS, 1MVT, 1OHJ, 1OHK, 1PD8, 1PD9, 1PDB, 1S3U, 1S3V, 1S3W, 1U71, 1U72, 1YHO, 2C2S, 2C2T, 2DHF, 2W3A, 2W3B, 2W3M, 3EIG, 3F8Y, 3F8Z, 3F91, 3FS6, 3GHC, 3GHV, 3GHW, 3GI2, 3GYF, 3L3R, 3N0H, 3NTZ, 3NU0, 3NXO, 3NXR, 3NXT, 3NXV, 3NXX, 3NXY, 3NZD, 3OAF, 3S3V, 3S7A, 4DDR, 4G95, 4KAK, 4KBN, 4KD7, 4KEB, 4KFJ, 4M6J, 4M6K, 4M6L, 4QHV, 4QJC
Identifiers
Aliases	DHFR, DHFRP1, DYR, dihydrofolate reductase
External IDs	OMIM: 126060 MGI: 94890 HomoloGene: 56470 GeneCards: DHFR
Targeted by Drug
methotrexate, pemetrexed, pralatrexate, trimetrexate
Gene ontology Molecular function • methotrexate binding • folic acid binding • dihydrofolate reductase activity • NADP binding • drug binding • NADPH binding • RNA binding • oxidoreductase activity • mRNA binding • folate reductase activity Cellular component • cytosol • nucleoplasm • cytoplasm • mitochondrion Biological process • nucleotide biosynthetic process • response to methotrexate • dihydrofolate metabolic process • one-carbon metabolic process • axon regeneration • G1/S transition of mitotic cell cycle • regulation of transcription involved in G1/S transition of mitotic cell cycle • tetrahydrofolate metabolic process • tetrahydrofolate biosynthetic process • positive regulation of nitric-oxide synthase activity • folic acid metabolic process • tetrahydrobiopterin biosynthetic process • glycine biosynthetic process • oxidation-reduction process • regulation of removal of superoxide radicals Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1719	13361
Ensembl	ENSG00000228716	ENSMUSG00000021707
UniProt	P00374	P00375
RefSeq (mRNA)	NM_000791 NM_001290354 NM_001290357	NM_010049
RefSeq (protein)	NP_000782 NP_001277283 NP_001277286	NP_034179.1 NP_034179
Location (UCSC)	Chr 5: 80.63 – 80.65 Mb	Chr 13: 92.35 – 92.39 Mb
PubMed search

1BOZ, 1DHF, 1DLR, 1DLS, 1DRF, 1HFP, 1HFQ, 1HFR, 1KMS, 1KMV, 1MVS, 1MVT, 1OHJ, 1OHK, 1PD8, 1PD9, 1PDB, 1S3U, 1S3V, 1S3W, 1U71, 1U72, 1YHO, 2C2S, 2C2T, 2DHF, 2W3A, 2W3B, 2W3M, 3EIG, 3F8Y, 3F8Z, 3F91, 3FS6, 3GHC, 3GHV, 3GHW, 3GI2, 3GYF, 3L3R, 3N0H, 3NTZ, 3NU0, 3NXO, 3NXR, 3NXT, 3NXV, 3NXX, 3NXY, 3NZD, 3OAF, 3S3V, 3S7A, 4DDR, 4G95, 4KAK, 4KBN, 4KD7, 4KEB, 4KFJ, 4M6J, 4M6K, 4M6L, 4QHV, 4QJC