EZH2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4MI0, 4MI5, 5HYN, 5IJ8, 5IJ7

Identifiers

Aliases

EZH2, ENX-1, ENX1, EZH1, EZH2b, KMT6, KMT6A, WVS, WVS2, enhancer of zeste 2 polycomb repressive complex 2 subunit

External IDs

MGI: 107940 HomoloGene: 37926 GeneCards: EZH2

Gene ontology
Molecular function	• methyltransferase activity • sequence-specific DNA binding • transferase activity • core promoter binding • promoter-specific chromatin binding • chromatin binding • histone-lysine N-methyltransferase activity • regulatory region DNA binding • protein-lysine N-methyltransferase activity • protein binding • RNA binding • ribonucleoprotein complex binding • chromatin DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • primary miRNA binding • DNA binding • histone methyltransferase activity • histone methyltransferase activity (H3-K27 specific)
Cellular component	• ESC/E(Z) complex • pronucleus • nuclear chromatin • nucleus • nucleoplasm • cytoplasm
Biological process	• regulation of protein phosphorylation • regulation of gliogenesis • response to estradiol • regulation of transcription, DNA-templated • positive regulation of MAP kinase activity • rhythmic process • negative regulation of retinoic acid receptor signaling pathway • regulation of transcription from RNA polymerase II promoter • negative regulation of striated muscle cell differentiation • G1 to G0 transition • negative regulation of transcription from RNA polymerase II promoter • chromatin organization • positive regulation of dendrite development • positive regulation of epithelial to mesenchymal transition • negative regulation of transcription elongation from RNA polymerase II promoter • transcription, DNA-templated • negative regulation of sequence-specific DNA binding transcription factor activity • positive regulation of protein serine/threonine kinase activity • negative regulation of gene expression • negative regulation of G1/S transition of mitotic cell cycle • histone H3-K27 methylation • positive regulation of GTPase activity • DNA methylation • negative regulation of epidermal cell differentiation • methylation • negative regulation of gene expression, epigenetic • regulation of cell proliferation • regulation of circadian rhythm • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration • cerebellar cortex development • regulation of gene expression • negative regulation of transcription, DNA-templated • protein localization to chromatin • hippocampus development • regulation of neurogenesis • cellular response to hydrogen peroxide • response to tetrachloromethane • cellular response to trichostatin A • covalent chromatin modification • histone H3-K27 trimethylation • cardiac muscle hypertrophy in response to stress • hepatocyte homeostasis • liver regeneration • histone methylation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


2146


14056

Ensembl


ENSG00000106462


ENSMUSG00000029687

UniProt


Q15910


Q61188

RefSeq (mRNA)


NM_001203247 NM_001203248 NM_001203249 NM_004456 NM_152998


NM_001146689 NM_007971

RefSeq (protein)


NP_001190176 NP_001190177 NP_001190178 NP_004447 NP_694543


NP_031997.2 NP_001140161 NP_031997

Location (UCSC)

Chr 7: 148.81 – 148.88 Mb

Chr 6: 47.53 – 47.6 Mb

PubMed search

Histone-lysine N-methyltransferase

Identifiers

Databases

PDB structures

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NCBI	proteins

4MI0, 4MI5, 5HYN, 5IJ8, 5IJ7

NM_001203247
NM_001203248
NM_001203249
NM_004456
NM_152998

NM_001146689
NM_007971

NP_001190176
NP_001190177
NP_001190178
NP_004447
NP_694543

...
Wikipedia