Enamelin

ENAM
Identifiers
Aliases	ENAM, ADAI, AI1C, AIH2, enamelin
External IDs	MGI: 1333772 HomoloGene: 9698 GeneCards: ENAM
Gene ontology Molecular function • structural constituent of tooth enamel • protein binding Cellular component • proteinaceous extracellular matrix • extracellular region • endoplasmic reticulum lumen Biological process • odontogenesis of dentin-containing tooth • biomineral tissue development • amelogenesis • regulation of cell morphogenesis • ameloblast differentiation • positive regulation of enamel mineralization • post-translational protein modification • cellular protein metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10117	13801
Ensembl	ENSG00000132464	ENSMUSG00000029286
UniProt	Q9NRM1	O55196
RefSeq (mRNA)	NM_031889	NM_017468
RefSeq (protein)	NP_114095	NP_059496.1 NP_059496
Location (UCSC)	Chr 4: 70.63 – 70.69 Mb	Chr 5: 88.49 – 88.51 Mb
PubMed search

Enamelin
Identifiers
Symbol	Enamelin
Pfam	PF15362
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

10117

13801

ENSG00000132464

ENSMUSG00000029286

Q9NRM1

O55196

NM_031889

NM_017468

NP_114095

NP_059496.1
NP_059496

Enamelin is a protein that in humans is encoded by the ENAM gene.

Dental enamel is a highly mineralized tissue with 85% of its volume occupied by unusually large, highly organized, hydroxyapatite crystals. This highly organized and unusual structure is thought to be rigorously controlled in ameloblasts through the interaction of a number of organic matrix molecules that include enamelin, amelogenin (AMELX; MIM 300391), ameloblastin (AMBN; MIM 601259), tuftelin (TUFT1; MIM 600087), dentine sialophosphoprotein (DSPP; MIM 125485), and a variety of enzymes. Enamelin is the largest protein in the enamel matrix of developing teeth and comprises approximately 5% of total enamel matrix protein.[supplied by OMIM]

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