Exosome component 3

EXOSC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NN6
Identifiers
Aliases	EXOSC3, PCH1B, RRP40, Rrp40p, bA3J10.7, hRrp-40, p10, CGI-102, Exosome component 3
External IDs	MGI: 1913612 HomoloGene: 6867 GeneCards: EXOSC3
Gene location (Human) Chr. Chromosome 9 (human) Band 9p13.2 Start 37,766,978 bp End 37,801,437 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 B1 Start 45,316,613 bp End 45,342,732 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • 3'-5'-exoribonuclease activity • exoribonuclease activity • protein binding • RNA binding Cellular component • transcriptionally active chromatin • cytosol • nuclear exosome (RNase complex) • cytoplasmic exosome (RNase complex) • nucleus • cytoplasm • exosome (RNase complex) • nucleolus • nucleoplasm Biological process • nuclear polyadenylation-dependent tRNA catabolic process • exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • regulation of mRNA stability • polyadenylation-dependent snoRNA 3'-end processing • DNA deamination • nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription • CUT catabolic process • nuclear polyadenylation-dependent rRNA catabolic process • positive regulation of isotype switching • isotype switching • nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' • U4 snRNA 3'-end processing • rRNA processing • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51010	66362
Ensembl	ENSG00000107371	ENSMUSG00000028322
UniProt	Q9NQT5	Q7TQK4
RefSeq (mRNA)	NM_016042 NM_001002269	NM_025513
RefSeq (protein)	NP_001002269 NP_057126	NP_079789
Location (UCSC)	Chr 9: 37.77 – 37.8 Mb	Chr 9: 45.32 – 45.34 Mb
PubMed search

2NN6

51010

66362

ENSG00000107371

ENSMUSG00000028322

Q9NQT5

Q7TQK4

NM_016042
NM_001002269

NM_025513

NP_001002269
NP_057126

NP_079789

Exosome component 3, also known as EXOSC3, is a human gene, which is part of the exosome complex.

Mutations in EXOSC3 cause and spinal motor neuron degeneration.

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Wikipedia