FBN1

FBN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1APJ, 1EMN, 1EMO, 1LMJ, 1UZJ, 1UZK, 1UZP, 1UZQ, 2M74, 2W86
Identifiers
Aliases	FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2, MFLS, fibrillin 1
External IDs	MGI: 95489 HomoloGene: 30958 GeneCards: FBN1
Genetically Related Diseases
breast cancer
Gene ontology Molecular function • calcium ion binding • extracellular matrix constituent conferring elasticity • protein complex binding • extracellular matrix structural constituent • integrin binding • protein binding • hormone activity • heparin binding Cellular component • extracellular matrix • proteinaceous extracellular matrix • basement membrane • extracellular exosome • intracellular • extracellular region • microfibril • extracellular space Biological process • cellular response to transforming growth factor beta stimulus • skeletal system development • kidney development • embryonic eye morphogenesis • post-embryonic eye morphogenesis • cellular response to insulin-like growth factor stimulus • extracellular matrix disassembly • extracellular matrix organization • heart development • camera-type eye development • metanephros development • regulation of cellular response to growth factor stimulus • protein kinase A signaling • activation of protein kinase A activity • glucose metabolic process • cell adhesion mediated by integrin • glucose homeostasis • sequestering of BMP in extracellular matrix • sequestering of TGFbeta in extracellular matrix • negative regulation of osteoclast differentiation • negative regulation of osteoclast development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2200	14118
Ensembl	ENSG00000166147	ENSMUSG00000027204
UniProt	P35555	Q61554
RefSeq (mRNA)	NM_000138	NM_007993
RefSeq (protein)	NP_000129	NP_032019
Location (UCSC)	Chr 15: 48.41 – 48.65 Mb	Chr 2: 125.3 – 125.51 Mb
PubMed search

1APJ, 1EMN, 1EMO, 1LMJ, 1UZJ, 1UZK, 1UZP, 1UZQ, 2M74, 2W86

2200

14118

ENSG00000166147

ENSMUSG00000027204

P35555

Q61554

NM_000138

NM_007993

NP_000129

NP_032019

Fibrillin-1 is a protein that in humans is encoded by the FBN1 gene, located on chromosome 15.

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Wikipedia