Fork head domain
| Fork head domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Structure of the winged helix protein Genesis.
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| Identifiers | |||||||||
| Symbol | Fork_head | ||||||||
| Pfam | PF00250 | ||||||||
| InterPro | IPR001766 | ||||||||
| SMART | SM00339 | ||||||||
| PROSITE | PDOC00564 | ||||||||
| SCOP | 2hfh | ||||||||
| SUPERFAMILY | 2hfh | ||||||||
| CDD | cd00059 | ||||||||
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| Available protein structures: | |
|---|---|
| Pfam | structures |
| PDB | RCSB PDB; PDBe; PDBj |
| PDBsum | structure summary |
The fork head domain is a type of protein domain that is often found in transcription factors and whose purpose is to bind DNA.
The fork head protein of Drosophila melanogaster, a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian , human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a "winged helix". The fork head domain binds B-DNA as a monomer, but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis. Members of the class O of forkhead box transcription factors (FoxO) have important roles in metabolism, cellular proliferation, stress tolerance and probably lifespan.
This article incorporates text from the public domain Pfam and InterPro IPR001766
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