GHMP kinase family
| GHMP kinases N terminal domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
crystal structure of the streptococcus pneumoniae phosphomevalonate kinase (pmk)
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| Identifiers | |||||||||
| Symbol | GHMP_kinases_N | ||||||||
| Pfam | PF00288 | ||||||||
| Pfam clan | CL0329 | ||||||||
| InterPro | IPR006204 | ||||||||
| PROSITE | PDOC00545 | ||||||||
| SCOP | 1fwl | ||||||||
| SUPERFAMILY | 1fwl | ||||||||
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| Available protein structures: | |
|---|---|
| Pfam | structures |
| PDB | RCSB PDB; PDBe; PDBj |
| PDBsum | structure summary |
| GHMP kinases C terminal | |||||||||
|---|---|---|---|---|---|---|---|---|---|
pyrococcus furiosus galactokinase in complex with galactose, adp and magnesium
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| Identifiers | |||||||||
| Symbol | GHMP_kinases_C | ||||||||
| Pfam | PF08544 | ||||||||
| InterPro | IPR013750 | ||||||||
| PROSITE | PDOC00545 | ||||||||
| SCOP | 1fwl | ||||||||
| SUPERFAMILY | 1fwl | ||||||||
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| Available protein structures: | |
|---|---|
| Pfam | structures |
| PDB | RCSB PDB; PDBe; PDBj |
| PDBsum | structure summary |
In molecular biology, the GHMP kinase family is a family of kinase enzymes. Members of this family include homoserine kinases EC 2.7.1.39, galactokinases EC 2.7.1.6, and mevalonate kinasesEC 2.7.1.36. These kinases make up the GHMP kinase superfamily of ATP-dependent enzymes. These enzymes are involved in the biosynthesis of isoprenes and amino acids as well as in carbohydrate metabolism. These enzymes contain, in their N-terminal section, a conserved Gly/Ser-rich region which is probably involved in the binding of ATP. The C-terminal domain of homoserine kinase has a central alpha-beta plait fold and an insertion of four helices, which, together with the N-terminal fold, creates a novel nucleotide binding fold.
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