GP5

GP5
Identifiers
Aliases	GP5, CD42d, GPV, glycoprotein V platelet
External IDs	MGI: 1096363 HomoloGene: 74523 GeneCards: GP5
Gene ontology Molecular function • protein binding Cellular component • integral component of membrane • plasma membrane • integral component of plasma membrane • extracellular exosome • membrane • proteinaceous extracellular matrix • extracellular space Biological process • platelet activation • blood coagulation, intrinsic pathway • hemostasis • cell adhesion • blood coagulation • axonogenesis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2814	14729
Ensembl	ENSG00000178732	ENSMUSG00000047953
UniProt	P40197	O08742 Q9QZU3
RefSeq (mRNA)	NM_004488	NM_008148
RefSeq (protein)	NP_004479	NP_032174
Location (UCSC)	Chr 3: 194.39 – 194.4 Mb	Chr 16: 30.31 – 30.31 Mb
PubMed search

2814

14729

ENSG00000178732

ENSMUSG00000047953

P40197

O08742
Q9QZU3

NM_004488

NM_008148

NP_004479

NP_032174

Glycoprotein V (platelet) (GP5) also known as CD42d (Cluster of Differentiation 42d), is a human gene.

Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 193400) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder.[supplied by OMIM]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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