Growth differentiation factor-9

GDF9
Identifiers
Aliases	GDF9, entrez:2661, growth differentiation factor 9
External IDs	OMIM: 601918 MGI: 95692 HomoloGene: 3851 GeneCards: GDF9
Gene location (Human) Chr. Chromosome 5 (human) Band No data available Start 132,861,181 bp End 132,866,884 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band No data available Start 53,431,023 bp End 53,437,904 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transforming growth factor beta receptor binding • cytokine activity • growth factor activity Cellular component • cytoplasm • extracellular region • extracellular space Biological process • regulation of apoptotic process • positive regulation of pathway-restricted SMAD protein phosphorylation • oocyte growth • regulation of MAPK cascade • transforming growth factor beta receptor signaling pathway • SMAD protein signal transduction • female gamete generation • negative regulation of cell growth • BMP signaling pathway • cell development • positive regulation of cell proliferation • regulation of progesterone secretion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2661	14566
Ensembl	ENSG00000164404	ENSMUSG00000018238
UniProt	O60383	Q07105
RefSeq (mRNA)	NM_001288824 NM_001288825 NM_001288826 NM_001288827 NM_001288828 NM_005260	NM_008110
RefSeq (protein)	NP_001275753 NP_001275754 NP_001275755 NP_001275756 NP_001275757 NP_005251	NP_032136
Location (UCSC)	Chr 5: 132.86 – 132.87 Mb	Chr 5: 53.43 – 53.44 Mb
PubMed search

2661

14566

ENSG00000164404

ENSMUSG00000018238

O60383

Q07105

NM_005260

NM_008110

NP_005251

NP_032136

Growth/differentiation factor 9 is a protein that in humans is encoded by the GDF9 gene.

Growth factors synthesized by ovarian somatic cells directly affect oocyte growth and function. Growth differentiation factor-9 (GDF9) is expressed in oocytes and is thought to be required for ovarian folliculogenesis. GDF9 is a member of the transforming growth factor-beta (TGFβ) superfamily.

Growth differentiation factor 9 (GDF9) is an oocyte derived growth factor in the transforming growth factor ß (TGF-ß) superfamily. It is highly expressed in the oocyte and has a pivotal influence on the surrounding somatic cells, particularly granulosa, cumulus and theca cells. Paracrine interactions between the developing oocyte and its surrounding follicular cells is essential for the correct progression of both the follicle and the oocyte. GDF9 is essential for the overall process of folliculogenesis, oogenesis and ovulation and thus plays a major role in female fertility.

...
Wikipedia