HLA-DOA

HLA-DOA
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4I0P
Identifiers
Aliases	HLA-DOA, HLA-DNA, HLA-DZA, HLADZ, HLA-DOA, major histocompatibility complex, class II, DO alpha
External IDs	MGI: 95924 HomoloGene: 1601 GeneCards: HLA-DOA
Gene ontology Molecular function • MHC class II receptor activity • protein binding • MHC class II protein complex binding Cellular component • integral component of membrane • lysosomal membrane • endosome • plasma membrane • lysosome • MHC class II protein complex • endosome membrane • membrane Biological process • antigen processing and presentation of peptide or polysaccharide antigen via MHC class II • antigen processing and presentation • antigen processing and presentation of exogenous peptide antigen via MHC class II • immune response • negative regulation of antigen processing and presentation of peptide antigen via MHC class II • regulation of T cell differentiation • immune system process • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3111	15001
Ensembl	n/a	ENSMUSG00000024334
UniProt	P06340	n/a
RefSeq (mRNA)	NM_002119	NM_008206
RefSeq (protein)	NP_002110	n/a
Location (UCSC)	Chr 6: 33 – 33.01 Mb	Chr 17: 34.09 – 34.1 Mb
PubMed search

4I0P

3111

15001

n/a

ENSMUSG00000024334

P06340

n/a

NM_002119

NM_008206

NP_002110

n/a

HLA class II histocompatibility antigen, DO alpha chain is a protein that in humans is encoded by the HLA-DOA gene.

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.

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