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HRH3

HRH3
Identifiers
Aliases HRH3, GPCR97, HH3R, histamine receptor H3
External IDs MGI: 2139279 HomoloGene: 5232 GeneCards: HRH3
Targeted by Drug
dimaprit, histamine, imetit, Immepip, Immethridine, Impentamine, methimepip, proxyfan, , impromidine, ciproxifan, clobenpropit, conessine, jnj-5207852, pitolisant, thioperamide, abt-239
RNA expression pattern
PBB GE HRH3 220447 at tn.png

PBB GE HRH3 221663 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007232

NM_133849

RefSeq (protein)

NP_009163

NP_598610.1
NP_598610

Location (UCSC) Chr 20: 62.21 – 62.22 Mb Chr 2: 180.1 – 180.1 Mb
PubMed search

NM_007232

NM_133849

NP_009163

NP_598610.1
NP_598610

Histamine H3 receptors are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where they act as autoreceptors in presynaptic histaminergic neurons, and also control histamine turnover by feedback inhibition of histamine synthesis and release. The H3 receptor has also been shown to presynaptically inhibit the release of a number of other neurotransmitters (i.e. it acts as an inhibitory heteroreceptor) including, but probably not limited to dopamine, GABA, acetylcholine, noradrenaline, histamine and serotonin.


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Wikipedia

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