Histamine H3 receptor

HRH3
Identifiers
Aliases	HRH3, GPCR97, HH3R, histamine receptor H3
External IDs	MGI: 2139279 HomoloGene: 5232 GeneCards: HRH3
Targeted by Drug
dimaprit, histamine, imetit, Immepip, Immethridine, Impentamine, methimepip, proxyfan, , impromidine, ciproxifan, clobenpropit, conessine, jnj-5207852, pitolisant, thioperamide, abt-239
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • histamine receptor activity Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • presynapse • synapse Biological process • regulation of norepinephrine secretion • regulation of neurotransmitter levels • G-protein coupled receptor signaling pathway • negative regulation of glutamate secretion • cognition • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • negative regulation of serotonin secretion • neurotransmitter secretion • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11255	99296
Ensembl	ENSG00000101180	ENSMUSG00000039059
UniProt	Q9Y5N1	P58406
RefSeq (mRNA)	NM_007232	NM_133849
RefSeq (protein)	NP_009163	NP_598610.1 NP_598610
Location (UCSC)	Chr 20: 62.21 – 62.22 Mb	Chr 2: 180.1 – 180.1 Mb
PubMed search

11255

99296

ENSG00000101180

ENSMUSG00000039059

Q9Y5N1

P58406

NM_007232

NM_133849

NP_009163

NP_598610.1
NP_598610

Histamine H₃ receptors are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where they act as autoreceptors in presynaptic histaminergic neurons, and also control histamine turnover by feedback inhibition of histamine synthesis and release. The H₃ receptor has also been shown to presynaptically inhibit the release of a number of other neurotransmitters (i.e. it acts as an inhibitory heteroreceptor) including, but probably not limited to dopamine, GABA, acetylcholine, noradrenaline, histamine and serotonin.

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