Hydroxyflutamide

Hydroxyflutamide

Identifiers
IUPAC name 2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
Synonyms	Hydroxyniphtholide, hydroxyniftolide; α,α,α-trifluoro-2-methyl-4'-nitro-m-lactotoluidide
CAS Number	52806-53-8
PubChem CID	91649
IUPHAR/BPS	2862
ChemSpider	82752
UNII	31D90UKP5Y
KEGG	C14204
ChEBI	CHEBI:43064
ChEMBL	CHEMBL491
ECHA InfoCard	100.169.708
Chemical and physical data
Formula	C11H11F3N2O4
Molar mass	292.21125 g/mol
3D model (Jmol)	Interactive image
SMILES CC(C)(C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F)O
InChI InChI=1S/C11H11F3N2O4/c1-10(2,18)9(17)15-6-3-4-8(16(19)20)7(5-6)11(12,13)14/h3-5,18H,1-2H3,(H,15,17) Key:YPQLFJODEKMJEF-UHFFFAOYSA-N

Hydroxyflutamide (HF, OHF) (developmental code name SCH-16423), or 2-hydroxyflutamide, is a non-steroidal antiandrogen. It is the major active metabolite of flutamide. It is reported to possess an IC₅₀ of 700 nM for the androgen receptor (AR), about 4-fold less than that of bicalutamide.