KREMEN1

KREMEN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5FWS, 5FWT, 5FWV
Identifiers
Aliases	KREMEN1, KREMEN, KRM1, kringle containing transmembrane protein 1, ECTD13
External IDs	MGI: 1933988 HomoloGene: 12935 GeneCards: KREMEN1
Gene ontology Molecular function • protein binding Cellular component • integral component of membrane • membrane • plasma membrane Biological process • regulation of canonical Wnt signaling pathway • cell communication • Wnt signaling pathway • apoptotic process • negative regulation of ossification • limb development • negative regulation of canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	83999	84035
Ensembl	ENSG00000183762	ENSMUSG00000020393
UniProt	Q96MU8	Q99N43
RefSeq (mRNA)	NM_001039570 NM_032045 NM_153379	NM_032396
RefSeq (protein)	NP_001034659 NP_114434	NP_115772
Location (UCSC)	Chr 22: 29.07 – 29.17 Mb	Chr 11: 5.19 – 5.26 Mb
PubMed search

5FWS, 5FWT, 5FWV

83999

84035

ENSG00000183762

ENSMUSG00000020393

Q96MU8

Q99N43

NM_001039570
NM_032045
NM_153379

NM_032396

NP_001034659
NP_114434

NP_115772

Kremen protein 1 is a protein that in humans is encoded by the KREMEN1 gene.Kremen1 is conserved in chordates including amphioxus and most vertebrate species. The protein is a type I transmembrane receptor of ligands Dickkopf1, Dickkopf2, Dickkopf3, Dickkopf4, EpCAM and Rspondin1.

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.

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