LY294002

LY294002

Names
IUPAC name 2-Morpholin-4-yl-8-phenylchromen-4-one
Other names 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
Identifiers
CAS Number	154447-36-6 Y
3D model (Jmol)	Interactive image
ChEMBL	ChEMBL98350 N
ChemSpider	3835 N
IUPHAR/BPS	6004
PubChem	3973
InChI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2 N Key: CZQHHVNHHHRRDU-UHFFFAOYSA-N N InChI=1/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2 Key: CZQHHVNHHHRRDU-UHFFFAOYAM
SMILES C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4
Properties
Chemical formula	C19H17NO3
Molar mass	307.35 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N  (what is YN ?)
Infobox references

LY294002 is a morpholine-containing chemical compound that is a potent inhibitor of numerous proteins, and a strong inhibitor of phosphoinositide 3-kinases (PI3Ks). It is generally considered a non-selective research tool, and should not be used for experiments aiming to target PI3K uniquely.

Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-4,5-bisphosphate 3-kinase P110 gamma|catalytic subunit gamma isoform. With an IC₅₀ of 1.4 µM it is somewhat less potent than wortmannin, another well-known PI3 kinase inhibitor. However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly.

Application of LY294002 causes a substantial acceleration of MEPP frequency (150 μM) at the frog neuromuscular junction through a mechanism that is independent of intraterminal calcium. LY294002 causes the release of MEPPs through a perturbation of synaptotagmin function.

LY294002 is also a BET inhibitor (eg of BRD2, BRD3, and BRD4).

It has been shown that LY294002 administration has an additive effect on quercetin antiviral activity against hepatitis C virus.