NCK1

NCK1

Protein NCK1 PDB 2ci8.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2CI8, 2CI9, 2JS0, 2JS2, 2JW4

Identifiers

NCK1, NCK, NCKalpha, nck-1, NCK adaptor protein 1

External IDs

MGI: 109601 HomoloGene: 38148 GeneCards: NCK1

Gene ontology
Molecular function	• protein binding, bridging • protein domain specific binding • receptor tyrosine kinase binding • protein kinase inhibitor activity • protein binding • cytoskeletal adaptor activity • receptor signaling complex scaffold activity • receptor binding • SH3/SH2 adaptor activity • eukaryotic initiation factor eIF2 binding • ephrin receptor binding • cadherin binding
Cellular component	• cytosol • ribosome • cell-cell junction • vesicle membrane • protein phosphatase type 1 complex • endoplasmic reticulum • nucleus • cytoplasm • plasma membrane
Biological process	• positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • Fc-gamma receptor signaling pathway involved in phagocytosis • actin filament organization • positive regulation of translation in response to endoplasmic reticulum stress • substrate-dependent cell migration, cell extension • signal complex assembly • negative regulation of cell death • positive regulation of cap-independent translational initiation • positive regulation of cap-dependent translational initiation • peptidyl-serine dephosphorylation • vascular endothelial growth factor receptor signaling pathway • response to other organism • positive regulation of T cell proliferation • negative regulation of peptidyl-serine phosphorylation • negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation • T cell receptor signaling pathway • negative regulation of PERK-mediated unfolded protein response • cell migration • negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress • regulation of translation • T cell activation • lamellipodium assembly • positive regulation of transcription from RNA polymerase II promoter • negative regulation of protein kinase activity • positive regulation of actin filament polymerization • regulation of cell migration • ephrin receptor signaling pathway • positive regulation of neuron projection development
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE NCK1 204725 s at fs.png

PBB GE NCK1 211063 s at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


4690


17973


ENSG00000158092


ENSMUSG00000032475


P16333


Q99M51

RefSeq (mRNA)


NM_006153 NM_001190796 NM_001291999


NM_010878 NM_001324530

RefSeq (protein)


NP_001177725 NP_001278928 NP_006144


NP_035008.2 NP_001311459 NP_035008

Location (UCSC)

Chr 3: 136.86 – 136.95 Mb

Chr 9: 100.49 – 100.55 Mb

PubMed search

2CI8, 2CI9, 2JS0, 2JS2, 2JW4

ENSG00000158092

ENSMUSG00000032475

NM_006153
NM_001190796
NM_001291999

NM_010878
NM_001324530

NP_001177725
NP_001278928
NP_006144

NP_035008.2
NP_001311459
NP_035008

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Wikipedia

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