National Perinatal Epidemiology Unit

The National Perinatal Epidemiology Unit (NPEU) is a multi-disciplinary research unit at Oxford University. Their work involves randomized controlled trials, national surveillance programs and surveys and other research on maternal and infant health and care in the perinatal period (before, during and after birth). The early work of the NPEU in developing a register of perinatal trials and methods for synthesizing their results lay the foundations for the Cochrane Collaboration.

The mission of the NPEU is "...to produce methodologically rigorous research evidence to improve the care provided to women and their families during pregnancy, childbirth, the newborn period and early childhood as well as promoting the effective use of resources by perinatal health services.” Since its inception, a key area of its activities has been undertaking and supporting randomized controlled trials of the effects of perinatal care, now through the NPEU Clinical Trials Unit.

The NPEU runs the UK Obstetric Surveillance System (UKOSS), which is a national system studying rare disorders of pregnancy. In 2011, the Policy Research Unit in Maternal Health and Care (PRUMC) was established at the NPEU.

The NPEU was established in 1978 by the Department of Health at Oxford University, following a joint request for a national research institute by the Royal College of Obstetricians and Gynaecologists and the British Paediatric Association. The Department gave the unit the task of providing "information which can promote effective use of resources in the perinatal health services." From the beginning, the first NPEU Director, Iain Chalmers, was guided by the principles for evaluating effectiveness of health care described by Archie Cochrane in his book, Effectiveness and Efficiency: Random Reflections on Health Services.

From its early days, the NPEU was a leader in both randomized controlled trials to assess the effects of perinatal care, the retrieval of information, and the development and use of systematic reviews and meta-analyses to synthesize research results. The unit developed extensive national and international collaborations which were to form both the basis of its work and lay the foundations for the development of the Cochrane Collaboration.

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