Nobiletin

Nobiletin

Names
IUPAC name 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one
Other names Hexamethoxyflavone
Identifiers
CAS Number	478-01-3 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:7602 N
ChemSpider	65283 N
KEGG	C10112 N
PubChem CID	72344
InChI InChI=1S/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3 N Key: MRIAQLRQZPPODS-UHFFFAOYSA-N N InChI=1/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3 Key: MRIAQLRQZPPODS-UHFFFAOYAI
SMILES c1c(OC)c(OC)ccc1C2=CC(=O)c3c(OC)c(OC)c(OC)c(OC)c3O2
Properties
Chemical formula	C21H22O8
Molar mass	402.40 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N  (what is YN ?)
Infobox references

Nobiletin is a flavonoid isolated from citrus peels. It is an O-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment.

Nobiletin was found to have anti-inflammatory and anti-tumor invasion, proliferation, and metastasis in vitro and in animal studies. Nobiletin was also found to potentially inhibit cartilage degradation.

Nobiletin was shown to augment AMPA receptor activity and long-term potentiation in cell culture. Synergistic chemopreventive effects of nobiletin and atorvastatin on colon carcinogenesis have been described.