POLE3

POLE3
Identifiers
Aliases	POLE3, CHARAC17, CHRAC17, YBL1, p17, polymerase (DNA) epsilon 3, accessory subunit, DNA polymerase epsilon 3, accessory subunit
External IDs	MGI: 1933378 HomoloGene: 9694 GeneCards: POLE3
Gene ontology Molecular function • transferase activity • DNA binding • DNA-directed DNA polymerase activity • nucleotidyltransferase activity • protein binding • protein heterodimerization activity Cellular component • Ada2/Gcn5/Ada3 transcription activator complex • epsilon DNA polymerase complex • nucleus • nucleoplasm Biological process • DNA replication • histone H3 acetylation • DNA biosynthetic process • G1/S transition of mitotic cell cycle • DNA replication initiation • telomere maintenance via semi-conservative replication Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54107	59001
Ensembl	ENSG00000148229	ENSMUSG00000028394
UniProt	Q9NRF9	Q9JKP7
RefSeq (mRNA)	NM_001278255 NM_017443	NM_021498
RefSeq (protein)	NP_001265184 NP_059139	NP_067473
Location (UCSC)	Chr 9: 113.41 – 113.41 Mb	Chr 4: 62.52 – 62.53 Mb
PubMed search

54107

59001

ENSG00000148229

ENSMUSG00000028394

Q9NRF9

Q9JKP7

NM_001278255
NM_017443

NM_021498

NP_001265184
NP_059139

NP_067473

DNA polymerase epsilon subunit 3 is an enzyme that in humans is encoded by the POLE3 gene.

POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM]

POLE3 has been shown to interact with SMARCA5.

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Wikipedia