Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
| phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.3.67 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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| Search | |
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| PMC | articles |
| PubMed | articles |
| NCBI | proteins |
In enzymology, a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (EC 3.1.3.67) is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are phosphatidylinositol 3,4,5-trisphosphate and H2O, whereas its two products are phosphatidylinositol 4,5-bisphosphate and phosphate.
This enzyme class belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase. Other names in common use include PTEN,MMAC1, and phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase. PTEN also refers to a member of the class, phosphatase and tensin homolog. This enzyme class participates in 10 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, p53 signaling pathway, focal adhesion, tight junction, endometrial cancer, glioma, prostate cancer, melanoma, and small cell lung cancer. It employs one cofactor, magnesium.
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