Podoplanin

PDPN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WSR, 4YO0
Identifiers
Aliases	PDPN, AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, T1A2, TI1A, podoplanin
External IDs	MGI: 103098 HomoloGene: 4729 GeneCards: PDPN
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.21 Start 13,583,465 bp End 13,617,957 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • folic acid transporter activity • water channel activity • amino acid transmembrane transporter activity • water transmembrane transporter activity • receptor binding • protein binding • chaperone binding • chemokine binding Cellular component • integral component of membrane • integral component of plasma membrane • plasma membrane • membrane • tetraspanin-enriched microdomain • lamellipodium membrane • cytoplasmic vesicle • filopodium membrane • microvillus membrane • ruffle membrane • cell projection • leading edge of lamellipodium • cytoplasm • cytosol • basolateral plasma membrane • apical plasma membrane • cell junction • membrane raft • invadopodium • ruffle • lamellipodium • filopodium Biological process • folic acid transport • water transport • platelet activation • multicellular organism development • regulation of cell shape • amino acid transport • positive regulation of epithelial to mesenchymal transition • positive regulation of cell migration • Rho protein signal transduction • wound healing, spreading of cells • positive regulation of extracellular matrix disassembly • invadopodium organization • regulation of lamellipodium morphogenesis • cell morphogenesis • lymphangiogenesis • negative regulation of cell proliferation • lung development • negative regulation of apoptotic process • lymph node development • positive regulation of cellular component movement • lymphatic endothelial cell fate commitment • actin-mediated cell contraction • regulation of substrate adhesion-dependent cell spreading • positive regulation of platelet aggregation • regulation of myofibroblast contraction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10630	14726
Ensembl	ENSG00000162493	n/a
UniProt	Q86YL7	Q62011
RefSeq (mRNA)	NM_001006624 NM_001006625 NM_006474 NM_198389	NM_001290822 NM_010329
RefSeq (protein)	NP_001006625 NP_001006626 NP_006465 NP_938203	NP_001277751 NP_034459
Location (UCSC)	Chr 1: 13.58 – 13.62 Mb	n/a
PubMed search

3WSR, 4YO0

10630

14726

ENSG00000162493

n/a

Q86YL7

Q62011

NM_001006624
NM_001006625
NM_006474
NM_198389

NM_001290822
NM_010329

NP_001006625
NP_001006626
NP_006465
NP_938203

NP_001277751
NP_034459

Podoplanin is a protein that is encoded by the "PDPN" gene in humans and animals.

Podoplanin is a mucin-type protein with a mass of 36- to 43-kDa. It is relatively well conserved between species, with homologues in humans, mice, rats, dogs and hamsters.

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