Postsynaptic density-95

DLG4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KEF, 3I4W, 3K82, 3ZRT
Identifiers
Aliases	DLG4, PSD95, SAP-90, SAP90, Dlgh4, PSD-95, SAP90A, discs large homolog 4, discs large MAGUK scaffold protein 4
External IDs	MGI: 1277959 HomoloGene: 1047 GeneCards: DLG4
Gene ontology Molecular function • beta-1 adrenergic receptor binding • PDZ domain binding • protein complex binding • scaffold protein binding • guanylate kinase activity • P2Y1 nucleotide receptor binding • acetylcholine receptor binding • kinase binding • protein C-terminus binding • protein binding • ionotropic glutamate receptor binding • D1 dopamine receptor binding • protein phosphatase binding • neuroligin family protein binding • ligand-gated ion channel activity • Ras guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • juxtaparanode region of axon • endocytic vesicle membrane • synaptic membrane • postsynaptic membrane • cell projection • membrane • postsynaptic density • synaptic vesicle • extrinsic component of cytoplasmic side of plasma membrane • voltage-gated potassium channel complex • cortical cytoskeleton • plasma membrane • dendritic spine • synapse • excitatory synapse • cerebellar mossy fiber • axon • cell junction • dendrite • basolateral plasma membrane • endoplasmic reticulum • neuron spine • AMPA glutamate receptor complex • dendrite cytoplasm • ionotropic glutamate receptor complex • neuron projection terminus • cell periphery • cytosol • postsynaptic density membrane Biological process • receptor localization to synapse • regulation of grooming behavior • regulation of long-term neuronal synaptic plasticity • neuromuscular process controlling balance • protein complex assembly • negative regulation of receptor internalization • establishment of protein localization • positive regulation of cytosolic calcium ion concentration • learning • nervous system development • MAPK cascade • locomotory exploration behavior • regulation of NMDA receptor activity • AMPA glutamate receptor clustering • dendritic spine morphogenesis • vocalization behavior • positive regulation of synaptic transmission • establishment or maintenance of epithelial cell apical/basal polarity • positive regulation of excitatory postsynaptic potential • social behavior • synaptic vesicle maturation • protein localization to synapse • signal transduction • positive regulation of GTPase activity • ion transmembrane transport • GMP metabolic process • GDP metabolic process • chemical synaptic transmission Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1742	13385
Ensembl	ENSG00000132535	ENSMUSG00000020886
UniProt	P78352 O14909	Q62108
RefSeq (mRNA)	NM_001128827 NM_001365 NM_001321074 NM_001321075 NM_001321076 NM_001321077	NM_001109752 NM_007864
RefSeq (protein)	NP_001122299 NP_001308003 NP_001308004 NP_001308005 NP_001308006 NP_001356	NP_001103222.1 NP_031890.1 NP_001103222 NP_031890
Location (UCSC)	Chr 17: 7.19 – 7.22 Mb	Chr 11: 70.02 – 70.05 Mb
PubMed search

1KEF, 3I4W, 3K82, 3ZRT

1742

13385

ENSG00000132535

ENSMUSG00000020886

P78352
O14909

Q62108

NM_001321077

NM_001109752
NM_007864

NP_001356

NP_001103222.1
NP_031890.1
NP_001103222
NP_031890

PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (discs large homolog 4) gene.

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