Proprotein convertase 1

PCSK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KN6, 2KDT, 2KE3
Identifiers
Aliases	PCSK1, BMIQ12, NEC1, PC1, PC3, SPC3, proprotein convertase subtilisin/kexin type 1
External IDs	OMIM: 162150 MGI: 97511 HomoloGene: 379 GeneCards: PCSK1
Gene ontology Molecular function • peptidase activity • serine-type peptidase activity • endopeptidase activity • hydrolase activity • serine-type endopeptidase activity Cellular component • secretory granule lumen • transport vesicle • cytoplasmic vesicle • extracellular space Biological process • peptide biosynthetic process • cell-cell signaling • metabolic process • peptide hormone processing • proteolysis • protein processing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5122	18548
Ensembl	ENSG00000175426	ENSMUSG00000021587
UniProt	P29120	P63239
RefSeq (mRNA)	NM_001177876 NM_000439 NM_001177875	NM_013628
RefSeq (protein)	NP_000430 NP_001171346	NP_038656.1 NP_038656
Location (UCSC)	Chr 5: 96.39 – 96.43 Mb	Chr 13: 75.09 – 75.13 Mb
PubMed search

proprotein convertase 1
Identifiers
EC number	3.4.21.93
CAS number	99676-46-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

Search
PMC	articles
PubMed	articles
NCBI	proteins

1KN6, 2KDT, 2KE3

5122

18548

ENSG00000175426

ENSMUSG00000021587

P29120

P63239

NM_001177876
NM_000439
NM_001177875

NM_013628

NP_000430
NP_001171346

NP_038656.1
NP_038656

Proprotein convertase 1, also known as prohormone convertase, prohormone convertase 3, or neuroendocrine convertase 1 and often abbreviated as PC1/3 is an enzyme that in humans is encoded by the PCSK1 gene. PCSK1 and PCSK2 differentially cleave proopiomelanocortin and they act together to process proinsulin and proglucagon in pancreatic islets.

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