RAB8A

RAB8A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3QBT, 3TNF, 4LHV, 4LHW, 4LHX, 4LHY, 4LHZ, 4LI0
Identifiers
Aliases	RAB8A, MEL, RAB8, member RAS oncogene family
External IDs	MGI: 96960 HomoloGene: 100934 GeneCards: RAB8A
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.11 Start 16,111,629 bp End 16,134,234 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8 B3.3|8 34.84 cM Start 72,161,200 bp End 72,183,904 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • GDP binding • GTP binding • Rab GTPase binding • myosin V binding • protein binding • protein kinase binding • GTPase activity Cellular component • cytoplasm • ciliary basal body • recycling endosome • cytosol • endosome • centrosome • phagocytic vesicle membrane • Golgi apparatus • cell projection • membrane • postsynaptic density • synaptic vesicle • Golgi membrane • Butt • ciliary base • neuronal cell body • dendrite • phagocytic vesicle • centriole • extracellular exosome • cytoskeleton • cytoplasmic vesicle • extracellular matrix • plasma membrane • trans-Golgi network transport vesicle • trans-Golgi network membrane • dendritic spine • recycling endosome membrane • non-motile cilium • secretory granule membrane Biological process • regulation of long-term neuronal synaptic plasticity • regulation of protein transport • axonogenesis • vesicle docking involved in exocytosis • protein secretion • regulation of protein localization • cell projection organization • G2/M transition of mitotic cell cycle • Golgi vesicle fusion to target membrane • protein transport • membrane organization • protein localization to plasma membrane • cellular response to insulin stimulus • cilium morphogenesis • ciliary basal body docking • neurotransmitter receptor transport to postsynaptic membrane • regulation of autophagy • autophagy • post-translational protein modification • regulation of exocytosis • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4218	17274
Ensembl	ENSG00000167461	ENSMUSG00000003037
UniProt	P61006	P55258
RefSeq (mRNA)	NM_005370	NM_023126
RefSeq (protein)	NP_005361 NP_005361.2	NP_075615
Location (UCSC)	Chr 19: 16.11 – 16.13 Mb	Chr 19: 72.16 – 72.18 Mb
PubMed search

3QBT, 3TNF, 4LHV, 4LHW, 4LHX, 4LHY, 4LHZ, 4LI0

4218

17274

ENSG00000167461

ENSMUSG00000003037

P61006

P55258

NM_005370

NM_023126

NP_005361
NP_005361.2

NP_075615

Ras-related protein Rab-8A is a protein that in humans is encoded by the RAB8A gene.

The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrated. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.

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