RAPGEF2

RAPGEF2
Identifiers
Aliases	RAPGEF2, CNrasGEF, NRAPGEP, PDZ-GEF1, PDZGEF1, RA-GEF, RA-GEF-1, Rap-GEP, nRap GEP, Rap guanine nucleotide exchange factor 2
External IDs	MGI: 2659071 HomoloGene: 35477 GeneCards: RAPGEF2
Gene ontology Molecular function • calcium ion binding • protein binding • diacylglycerol binding • signal transducer activity • guanyl-nucleotide exchange factor activity • WW domain binding • phosphatidic acid binding • PDZ domain binding • cAMP binding • cGMP binding • beta-1 adrenergic receptor binding • GTPase activator activity • Rap guanyl-nucleotide exchange factor activity • Ras guanyl-nucleotide exchange factor activity Cellular component • cell-cell junction • endocytic vesicle • synapse • integral component of plasma membrane • apical plasma membrane • protein complex • bicellular tight junction • endosome • cell junction • neuron projection • neuronal cell body • cytoplasm • cytosol • late endosome • membrane • plasma membrane • perinuclear region of cytoplasm • intracellular Biological process • positive regulation of ERK1 and ERK2 cascade • brain-derived neurotrophic factor receptor signaling pathway • cellular response to cGMP • ventricular system development • positive regulation of protein binding • forebrain neuron development • regulation of cell junction assembly • protein localization to plasma membrane • positive regulation of neuron projection development • adenylate cyclase-activating adrenergic receptor signaling pathway • nervous system development • neuron migration • neuropeptide signaling pathway • multicellular organism development • G-protein coupled receptor signaling pathway • negative regulation of melanin biosynthetic process • cellular response to nerve growth factor stimulus • cell differentiation • positive regulation of cAMP-mediated signaling • intracellular signal transduction • cellular response to cAMP • nerve growth factor signaling pathway • regulation of cell proliferation • Rap protein signal transduction • small GTPase mediated signal transduction • negative regulation of cell proliferation • blood vessel development • positive regulation of dendritic cell apoptotic process • positive regulation of vasculogenesis • microvillus assembly • negative regulation of dendrite morphogenesis • regulation of synaptic plasticity • neuron projection development • establishment of endothelial intestinal barrier • positive regulation of cAMP-dependent protein kinase activity • positive regulation of neuron migration • positive regulation of protein kinase activity • establishment of endothelial barrier • signal transduction • MAPK cascade • positive regulation of GTPase activity • cAMP-mediated signaling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9693	76089
Ensembl	ENSG00000109756	ENSMUSG00000062232
UniProt	Q9Y4G8	Q8CHG7
RefSeq (mRNA)	NM_014247	NM_001099624 NM_001310536
RefSeq (protein)	NP_055062	NP_001093094 NP_001297465
Location (UCSC)	Chr 4: 159.1 – 159.36 Mb	Chr 3: 79.06 – 79.29 Mb
PubMed search

9693

76089

ENSG00000109756

ENSMUSG00000062232

Q9Y4G8

Q8CHG7

NM_014247

NM_001099624
NM_001310536

NP_055062

NP_001093094
NP_001297465

Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene.

RAPGEF2 is a cyclic AMP binding protein.

Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation.

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