RBMX

RBMX
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MB0, 2MKS
Identifiers
Aliases	RBMX, HNRNPG, HNRPG, RBMXP1, RBMXRT, RNMX, hnRNP-G, MRXS11, RNA binding motif protein, X-linked
External IDs	MGI: 1343044 HomoloGene: 20494 GeneCards: RBMX
Gene ontology Molecular function • protein binding • nucleic acid binding • mRNA binding • identical protein binding • RNA binding • core promoter binding • chromatin binding • single-stranded RNA binding Cellular component • nuclear euchromatin • catalytic step 2 spliceosome • membrane • supraspliceosomal complex • nucleoplasm • spliceosomal complex • extracellular exosome • nucleus • intracellular ribonucleoprotein complex • extracellular space Biological process • mRNA splicing, via spliceosome • gene expression • positive regulation of mRNA splicing, via spliceosome • mRNA processing • transcription from RNA polymerase II promoter • regulation of alternative mRNA splicing, via spliceosome • transcription, DNA-templated • negative regulation of mRNA splicing, via spliceosome • membrane protein ectodomain proteolysis • osteoblast differentiation • cellular response to interleukin-1 • protein homooligomerization • RNA splicing • positive regulation of transcription from RNA polymerase II promoter • mRNA splice site selection • positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27316	19655
Ensembl	ENSG00000147274	ENSMUSG00000031134
UniProt	P38159	Q9WV02
RefSeq (mRNA)	NM_001164803 NM_002139	NM_001166623 NM_011252
RefSeq (protein)	NP_001158275 NP_002130	NP_001160095.1 NP_035382.1 NP_001160095 NP_035382
Location (UCSC)	Chr X: 136.85 – 136.88 Mb	Chr X: 57.38 – 57.39 Mb
PubMed search

2MB0, 2MKS

27316

19655

ENSG00000147274

ENSMUSG00000031134

P38159

Q9WV02

NM_001164803
NM_002139

NM_001166623
NM_011252

NP_001158275
NP_002130

NP_001160095.1
NP_035382.1
NP_001160095
NP_035382

Heterogeneous nuclear ribonucleoprotein G is a protein that in humans is encoded by the RBMX gene.

This gene belongs to the RBMY gene family which includes candidate Y chromosome spermatogenesis genes. This gene, an active X chromosome homolog of the Y chromosome RBMY gene, is widely expressed whereas the RBMY gene evolved a male-specific function in spermatogenesis. Pseudogenes of this gene, found on chromosomes 1, 4, 9, 11, and 6, were likely derived by retrotransposition from the original gene. Alternatively spliced transcript variants encoding different isoforms have been identified but their biological nature has not been determined.

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