Rel homology domain
| Rel homology domain (RHD) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Top view of the crystallographic structure of a homodimer of the NFKB1 protein (green and magenta) bound to DNA (brown).
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| Identifiers | |||||||||
| Symbol | RHD | ||||||||
| Pfam | PF00554 | ||||||||
| InterPro | IPR011539 | ||||||||
| PROSITE | PDOC00924 | ||||||||
| SCOP | 1svc | ||||||||
| SUPERFAMILY | 1svc | ||||||||
| CDD | cd07827 | ||||||||
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| Available protein structures: | |
|---|---|
| Pfam | structures |
| PDB | RCSB PDB; PDBe; PDBj |
| PDBsum | structure summary |
The Rel homology domain (RHD) is a protein domain found in a family of eukaryotic transcription factors, which includes NF-κB, NFAT, among others. Some of these transcription factors appear to form multi-protein DNA-bound complexes.Phosphorylation of the RHD appears to play a role in the regulation of some of these transcription factors, acting to modulate the expression of their target genes. The RHD is composed of two immunoglobulin-like beta barrel subdomains that grip the DNA in the major groove. The N-terminal specificity domain resembles the core domain of the p53 transcription factor, and contains a recognition loop that interacts with DNA bases. The C-terminal dimerization domain contains the site for interaction with I-kappaB.
This article incorporates text from the public domain Pfam and InterPro IPR011539
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