Rs429358

APOE
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B68, 1BZ4, 1EA8, 1GS9, 1H7I, 1LE2, 1LE4, 1LPE, 1NFN, 1NFO, 1OEF, 1OEG, 1OR2, 1OR3, 2KC3, 2KNY, 2L7B
Identifiers
Aliases	APOE, AD2, APO-E, LDLCQ5, LPG, apolipoprotein E, ApoE4
External IDs	OMIM: 107741 MGI: 88057 HomoloGene: 30951 GeneCards: APOE
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.32 Start 44,905,754 bp End 44,909,393 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 A3|7 9.94 cM Start 19,696,109 bp End 19,699,188 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • heparin binding • very-low-density lipoprotein particle receptor binding • low-density lipoprotein particle receptor binding • lipoprotein particle binding • phosphatidylcholine-sterol O-acyltransferase activator activity • phospholipid binding • cholesterol transporter activity • protein homodimerization activity • amyloid-beta binding • protein binding • tau protein binding • metal chelating activity • lipid transporter activity • cholesterol binding • antioxidant activity • identical protein binding • lipid binding Cellular component • cytoplasm • membrane • chylomicron • extracellular region • cell nucleus • extracellular vesicle • endocytic vesicle lumen • very-low-density lipoprotein particle • • endoplasmic reticulum • extracellular exosome • Golgi apparatus • blood microparticle • extracellular matrix • plasma membrane • neuronal cell body • early endosome • low-density lipoprotein particle • dendrite • high-density lipoprotein particle • intermediate-density lipoprotein particle Biological process • negative regulation of neuron apoptotic process • response to dietary excess • negative regulation of lipid transport across blood brain barrier • lipid transport • positive regulation of lipid biosynthetic process • regulation of axon extension • positive regulation of postsynaptic membrane organization • positive regulation of cholesterol esterification • phospholipid efflux • cholesterol catabolic process • positive regulation of dendritic spine development • receptor-mediated endocytosis • retinoid metabolic process • positive regulation of amyloid-beta formation • lipid homeostasis • lipoprotein biosynthetic process • cholesterol homeostasis • negative regulation of inflammatory response • triglyceride metabolic process • negative regulation of canonical Wnt signaling pathway • negative regulation of dendritic spine maintenance • negative regulation of blood vessel endothelial cell migration • NMDA glutamate receptor clustering • response to reactive oxygen species • negative regulation of blood coagulation • positive regulation of cGMP biosynthetic process • response to oxidative stress • positive regulation of nitric-oxide synthase activity • negative regulation of phospholipid efflux • positive regulation of cholesterol efflux • negative regulation of MAP kinase activity • artery morphogenesis • very-low-density lipoprotein particle remodeling • regulation of neuronal synaptic plasticity • cardiovascular system development • negative regulation of dendritic spine development • negative regulation of cholesterol biosynthetic process • positive regulation of dendritic spine maintenance • positive regulation of phospholipid efflux • negative regulation of presynaptic membrane organization • negative regulation of neuron death • high-density lipoprotein particle clearance • long-chain fatty acid transport • lipoprotein metabolic process • regulation of tau-protein kinase activity • G-protein coupled receptor signaling pathway • chylomicron remnant clearance • cellular calcium ion homeostasis • cholesterol metabolic process • very-low-density lipoprotein particle clearance • virion assembly • negative regulation of lipid biosynthetic process • cGMP-mediated signaling • triglyceride catabolic process • positive regulation of presynaptic membrane organization • positive regulation of neurofibrillary tangle assembly • AMPA glutamate receptor clustering • positive regulation of low-density lipoprotein particle receptor catabolic process • positive regulation of lipid transport across blood brain barrier • fatty acid homeostasis • nitric oxide mediated signal transduction • transport • cholesterol efflux • regulation of gene expression • negative regulation of cholesterol efflux • regulation of amyloid-beta clearance • neuron projection regeneration • negative regulation of postsynaptic membrane organization • steroid metabolic process • regulation of Cdc42 protein signal transduction • lipid metabolic process • negative regulation of amyloid-beta formation • positive regulation of membrane protein ectodomain proteolysis • vasodilation • intracellular transport • synaptic transmission, cholinergic • positive regulation of neuron death • high-density lipoprotein particle assembly • protein import • high-density lipoprotein particle remodeling • negative regulation of endothelial cell proliferation • maintenance of location in cell • negative regulation of platelet activation • low-density lipoprotein particle remodeling • positive regulation by host of viral process • cytoskeleton organization • regulation of neuron death • reverse cholesterol transport • lipoprotein catabolic process • triglyceride homeostasis • cellular oxidant detoxification • lipid transport involved in lipid storage Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	348	11816
Ensembl	ENSG00000130203	ENSMUSG00000002985
UniProt	P02649	P08226
RefSeq (mRNA)	NM_001302691 NM_000041 NM_001302688 NM_001302689 NM_001302690	NM_009696 NM_001305819 NM_001305843 NM_001305844
RefSeq (protein)	NP_000032 NP_001289617 NP_001289618 NP_001289619 NP_001289620	NP_001292748 NP_001292772 NP_001292773 NP_033826
Location (UCSC)	Chr 19: 44.91 – 44.91 Mb	Chr 7: 19.7 – 19.7 Mb
PubMed search

SNP: Apolipoprotein E
Gene	ApoE
Chromosome	19
External databases
Ensembl	Human SNPView
dbSNP	429358
HapMap	429358
SNPedia	429358
HgenetInfoDB	429358

1B68, 1BZ4, 1EA8, 1GS9, 1H7I, 1LE2, 1LE4, 1LPE, 1NFN, 1NFO, 1OEF, 1OEG, 1OR2, 1OR3, 2KC3, 2KNY, 2L7B

348

11816

ENSG00000130203

ENSMUSG00000002985

P02649

P08226

NM_001302691
NM_000041
NM_001302688
NM_001302689
NM_001302690

...
Wikipedia