S-18986

S-18986
Legal status

Legal status	US: Investigational New Drug
Identifiers
IUPAC name (S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide
PubChem CID	637863
IUPHAR/BPS	4304
ChemSpider	553445^N
Chemical and physical data
Formula	C₁₀H₁₂N₂O₂S
Molar mass	224.279 g/mol
3D model (JSmol)	Interactive image
SMILES C1C[C@@H]2NS(=O)(=O)C3=CC=CC=C3N2C1
InChI InChI=1S/C10H12N2O2S/c13-15(14)9-5-2-1-4-8(9)12-7-3-6-10(12)11-15/h1-2,4-5,10-11H,3,6-7H2/t10-/m1/s1^N Key:MNTIJYGEITVWHU-SNVBAGLBSA-N^N
^NY (what is this?)

S-18986 is an ampakine drug related to cyclothiazide. It has nootropic and neuroprotective effects in animal studies, and induces both production of BDNF and AMPA-mediated release of noradrenaline and acetylcholine in the hippocampus and frontal cortex of the brain.