SDC2

SDC2
Identifiers
Aliases	SDC2, CD362, HSPG, HSPG1, SYND2, syndecan 2
External IDs	MGI: 1349165 HomoloGene: 2253 GeneCards: SDC2
Gene ontology Molecular function • PDZ domain binding • protein binding Cellular component • integral component of membrane • membrane • plasma membrane • lysosomal lumen • Golgi lumen Biological process • glycosaminoglycan metabolic process • cell differentiation • ephrin receptor signaling pathway • nervous system development • retinoid metabolic process • regulation of dendrite morphogenesis • bioluminescence • glycosaminoglycan catabolic process • glycosaminoglycan biosynthetic process • leukocyte migration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6383	15529
Ensembl	ENSG00000169439	ENSMUSG00000022261
UniProt	P34741	P43407
RefSeq (mRNA)	NM_002998	NM_008304
RefSeq (protein)	NP_002989	NP_032330.1 NP_032330
Location (UCSC)	Chr 8: 96.49 – 96.61 Mb	Chr 15: 32.92 – 33.03 Mb
PubMed search

6383

15529

ENSG00000169439

ENSMUSG00000022261

P34741

P43407

NM_002998

NM_008304

NP_002989

NP_032330.1
NP_032330

Syndecan-2 is a protein that in humans is encoded by the SDC2 gene.

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types.

SDC2 has been shown to interact with:

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Wikipedia