SEPX1

MSRB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MAO
Identifiers
Aliases	MSRB1, SELR, SELX, SEPX1, SepR, HSPC270, methionine sulfoxide reductase B1
External IDs	MGI: 1351642 HomoloGene: 8455 GeneCards: MSRB1
Gene ontology Molecular function • oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor • oxidoreductase activity • actin binding • zinc ion binding • metal ion binding • methionine-R-sulfoxide reductase activity • peptide-methionine (R)-S-oxide reductase activity Cellular component • cytoplasm • cytosol • cytoskeleton • nucleus • actin cytoskeleton Biological process • immune system process • actin filament polymerization • innate immune response • oxidation-reduction process • response to oxidative stress • protein repair Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51734	27361
Ensembl	ENSG00000198736	ENSMUSG00000075705
UniProt	Q9NZV6	Q9JLC3
RefSeq (mRNA)	NM_016332	NM_013759 NM_001346668
RefSeq (protein)	NP_057416	NP_038787.1 NP_001333597 NP_038787
Location (UCSC)	Chr 16: 1.94 – 1.94 Mb	Chr 17: 24.74 – 24.74 Mb
PubMed search

3MAO

51734

27361

ENSG00000198736

ENSMUSG00000075705

Q9NZV6

Q9JLC3

NM_016332

NM_013759
NM_001346668

NP_057416

NP_038787.1
NP_001333597
NP_038787

Methionine-R-sulfoxide reductase B1 is an enzyme that in humans is encoded by the SEPX1 gene.

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the methionine sulfoxide reductase B (MsrB) family, and it is expressed in a variety of adult and fetal tissues.

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