SFRS1

SRSF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X4A, 2M7S, 2M8D, 2O3D, 3BEG, 4C0O
Identifiers
Aliases	SRSF1, ASF, SF2, SF2p33, SFRS1, SRp30a, ASF/SF2, serine/arginine-rich splicing factor 1, serine and arginine rich splicing factor 1
External IDs	MGI: 98283 HomoloGene: 31411 GeneCards: SRSF1
Gene ontology Molecular function • nucleotide binding • RS domain binding • protein binding • RNA binding • nucleic acid binding • mRNA binding • protein kinase B binding Cellular component • cytoplasm • nuclear speck • catalytic step 2 spliceosome • exon-exon junction complex • nucleoplasm • spliceosomal complex • extracellular exosome • nucleus Biological process • mRNA splicing, via spliceosome • termination of RNA polymerase II transcription • mRNA transport • cardiac muscle contraction • mRNA processing • in utero embryonic development • mRNA export from nucleus • mRNA splice site selection • transport • mRNA 5'-splice site recognition • mRNA 3'-end processing • liver regeneration • alternative mRNA splicing, via spliceosome • RNA splicing • oligodendrocyte differentiation • RNA export from nucleus • positive regulation of RNA splicing Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6426	110809
Ensembl	ENSG00000136450	n/a
UniProt	Q07955	Q6PDM2
RefSeq (mRNA)	NM_001078166 NM_006924	NM_001078167 NM_173374
RefSeq (protein)	NP_001071634 NP_008855	NP_001071635.1 NP_775550.2 NP_001071635 NP_775550
Location (UCSC)	Chr 17: 58 – 58.01 Mb	Chr 11: 88.05 – 88.05 Mb
PubMed search

1X4A, 2M7S, 2M8D, 2O3D, 3BEG, 4C0O

6426

110809

ENSG00000136450

n/a

Q07955

Q6PDM2

NM_001078166
NM_006924

NM_001078167
NM_173374

NP_001071634
NP_008855

NP_001071635.1
NP_775550.2
NP_001071635
NP_775550

Serine/arginine-rich splicing factor 1 (SRSF1) also known as alternative splicing factor 1 (ASF1), pre-mRNA-splicing factor SF2 (SF2) or ASF1/SF2 is a protein that in humans is encoded by the SFRS1 gene. ASF/SF2 is an essential sequence specific splicing factor involved in pre-mRNA splicing. SFRS1 is the gene that codes for ASF/SF2 and is found on chromosome 17. The resulting splicing factor is a protein of approximately 33 kDa. ASF/SF2 is necessary for all splicing reactions to occur, and influences splice site selection in a concentration-dependent manner, resulting in alternative splicing. In addition to being involved in the splicing process, ASF/SF2 also mediates post-splicing activities, such as mRNA nuclear export and translation.

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