Sulfacetamide

Sulfacetamide
Clinical data


Trade names	Bleph-10
AHFS/Drugs.com	Monograph
MedlinePlus	a601114
ATC code	D10AF06 (WHO) S01AB04 (WHO), QJ01EQ21 (WHO)
Pharmacokinetic data
Biological half-life	7 to 12.8 hours
Identifiers
IUPAC name N-[(4-aminophenyl)sulfonyl]acetamide
CAS Number	144-80-9^Y
PubChem CID	5320
DrugBank	DB00634^Y
ChemSpider	5129^Y
UNII	4965G3J0F5
KEGG	D05947^Y
ChEMBL	CHEMBL455^Y
ECHA InfoCard	100.005.128
Chemical and physical data
Formula	C₈H₁₀N₂O₃S
Molar mass	214.243 g/mol
3D model (Jmol)	Interactive image
SMILES O=S(=O)(c1ccc(N)cc1)NC(=O)C
InChI InChI=1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)^Y Key:SKIVFJLNDNKQPD-UHFFFAOYSA-N^Y

Sulfacetamide is a sulfonamide antibiotic.

Sulfacetamide 10% topical lotion, sold under the brand name Klaron or Ovace, is approved for the treatment of acne and seborrheic dermatitis. When combined with sulfur, it is sold under the brand names Plexion, Clenia, Prascion, and Avar, which contain 10% sulfacetamide and 5% sulfur.

Sulfacetamide has been investigated for use in the treatment of pityriasis versicolor and rosacea. It also has anti-inflammatory properties when used to treat blepharitis or conjunctivitis (in eye-drop solution). It is believed to work by limiting the presence of folic acid which bacteria need to survive. It has been suggested that sulfacetamide may also serve as a treatment for mild forms of hidradenitis suppurativa. Sulfacetamide has antibacterial activity and is used to control acne. Products containing sulfacetamide and sulfur (a keratolytic) are commonly promoted for the treatment of acne rosacea (rosacea with papules, pustules, or both). There are several prescription topical products containing sulfacetamide, such as foams, shampoos, cream and washes.

Some research indicates that sulfacetamide derivatives may act as antifungals by an CYP51A1-independent mechanism.

Sulfacetamide, also known as acetosufamine belongs to the class of organic compounds known as aminobenzenesulfonamides. These are organic compounds containing an benzenesulfonamide moiety with an amine group attached to the benzene ring. The molecular structure is C₈H₁₀N₂O₃S. It's scientific name is N-(4-aminophenyl)sulfonylacetamide. At room temperature, it appears as a white powder.

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Wikipedia