TMEM66

SARAF
Identifiers
Aliases	SARAF, FOAP-7, TMEM66, XTP3, HSPC035, store-operated calcium entry associated regulatory factor
External IDs	MGI: 1915137 HomoloGene: 9398 GeneCards: SARAF
Gene ontology Molecular function • protein binding Cellular component • integral component of membrane • integral component of endoplasmic reticulum membrane • endoplasmic reticulum membrane • membrane • endoplasmic reticulum Biological process • ion transport • regulation of store-operated calcium entry • calcium ion transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51669	67887
Ensembl	ENSG00000133872	ENSMUSG00000031532
UniProt	Q96BY9	Q8R3Q0
RefSeq (mRNA)	NM_016127 NM_001284239	NM_026432
RefSeq (protein)	NP_001271168 NP_057211	NP_080708
Location (UCSC)	Chr 8: 30.06 – 30.08 Mb	Chr 8: 34.15 – 34.17 Mb
PubMed search

51669

67887

ENSG00000133872

ENSMUSG00000031532

Q96BY9

Q8R3Q0

NM_016127
NM_001284239

NM_026432

NP_001271168
NP_057211

NP_080708

SARAF is a protein that in humans is encoded by the SARAF gene, formerly known as TMEM66 (transmembrane protein 66).

SARAF (TMEM66) is a negative regulator of the store-operated calcium channel (SOCE) into cells. SARAF is an endoplasmic reticulum (ER) membrane resident protein that associates with STIM1, to facilitate the inactivation of SOCE. SARAF plays a key role in shaping cytoplasmic calcium signals and determining the content of the major intracellular Ca²⁺ stores in the cell. By doing so it is likely to be important in protecting cells from calcium overfilling.

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Wikipedia