Thomas J. Kelly (oncologist)
| Thomas J. Kelly | |
|---|---|
| Residence | New York City, New York |
| Nationality | American |
| Fields | Molecular biology, biochemistry |
| Institutions | Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center |
| Alma mater | Johns Hopkins University |
| Notable awards | Louisa Gross Horwitz Prize of Columbia UniversityAlfred P. Sloan, Jr. Prize of the General Motors Cancer Research Foundation. |
Thomas J. Kelly is an American cancer researcher whose work focuses on the molecular mechanisms of DNA replication. Kelly is director of the Sloan-Kettering Institute, the basic research arm of the Memorial Sloan-Kettering Cancer Center. He holds the Center's Benno C. Schmidt Chair of Cancer Research.
Before joining Sloan-Kettering in 2002, Kelly was professor and director of the Department of Molecular Biology and Genetics at the Johns Hopkins University School of Medicine and was the founding director of the Johns Hopkins Institute for Basic Biomedical Sciences.
Kelly pioneered the study of DNA replication in eukaryotic cells by using DNA viruses as model systems. His laboratory developed the first cell-free systems for studying the biochemistry of DNA replication in human cells, enabling the identification and functional characterization of components of the human replication machinery.
In recognition of this work he received the 2004 Alfred P. Sloan, Jr. Prize of the General Motors Cancer Research Foundation and the 2010 Louisa Gross Horwitz Prize of Columbia University.
Kelly earned a Ph.D. in biophysics in 1968 and an M.D. in 1969. While a postdoctoral fellow with Hamilton O. Smith at the Johns Hopkins University School of Medicine during 1969-70, Kelly determined the DNA sequences recognized by type II restriction enzymes, which subsequently became major tools in recombinant DNA research. In 1970 he moved to the National Institutes of Health as a member of the United States Public Health Service and conducted research on the DNA viruses, adenovirus and SV40, which cause tumors in animals. He joined the faculty in the Department of Microbiology at the Johns Hopkins University School of Medicine in 1972, where he began to exploit viruses as potentially powerful model systems for exploring the mechanisms of DNA replication in human cells.
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