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Triazole


A triazole (Htrz) refers to any of the heterocyclic compounds with molecular formula C2H3N3, having a five-membered ring of two carbon atoms and three nitrogen atoms. There are two sets of isomers that differ in the relative positions of the three nitrogen atoms. Each of these has two tautomers that differ by which nitrogen has a hydrogen bonded to it:

1H-1,2,3-Triazole

2H-1,2,3-Triazole

1H-1,2,4-Triazole

4H-1,2,4-Triazole

The triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole.

The triazole plant protection fungicides include epoxiconazole, triadimenol, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.

Paclobutrazol and uniconazole are used as plant growth retardants.

Benzotriazole is used in chemical photography as a restrainer and fog-suppressant.

Due to spreading resistance of plant pathogens towards fungicides of the strobilurin class, control of fungi such as Septoria tritici or Gibberella zeae relies heavily on triazoles. Food, like store bought potatoes, contain retardants such as triazole or tetcyclacis.


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