| U.S. Route 378 | |||||||
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| Route information | |||||||
| Auxiliary route of US 78 | |||||||
| Length: | 234.30 mi (377.07 km) | ||||||
| Existed: | 1952 – present | ||||||
| Major junctions | |||||||
| West end: |
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| East end: |
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| Location | |||||||
| States: | Georgia, South Carolina | ||||||
| Counties: |
GA: Wilkes, Lincoln SC: McCormick, Edgefield, Saluda, Lexington, Richland, Sumter, Clarendon, Florence, Marion, Horry |
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| Highway system | |||||||
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U.S. Route 378 Business |
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| Location: | Sumter, South Carolina |
| Length: | 6.6 mi (10.6 km) |
| Existed: | 1961–N/A |
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U.S. Route 378 Business |
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| Location: | Lake City, South Carolina |
| Length: | 4.49 mi (7.23 km) |
| Existed: | 1958–present |
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