U.S. Route 385 in Texas
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| Route information | ||||
| Maintained by TxDOT | ||||
| Length: | 441.309 mi (710.218 km) | |||
| Existed: | 1927 – present | |||
| Major junctions | ||||
| South end: |
 Big Bend National Park
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 I-10 in  I-20 in Odessa I-40 in Vega
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| North end: |
 US-385 at Oklahoma state line |
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U.S. Route 385 (US 385) is a north-south U.S. highway that runs from Big Bend National Park in Texas to Deadwood, South Dakota. In Texas, the highway runs from Big Bend National Park to the Oklahoma state line, north of Dalhart.
US 385 is part of the La Entrada al Pacifico trade corridor from Interstate 10 in to Interstate 20 in Odessa.
US 385 begins at Big Bend National Park near the Permission Gap Visitor Center. About 70 miles to the north, the highway intersects US 90 in the town of Marathon, sharing a short overlap with that highway. In , US 385 begins an overlap with Interstate 10 and US 67. At I-10 exit 273, US 67/385 end their overlap with the interstate, running in a northeast direction. US 385 ends its overlap with US 67 in McCamey, running in a slight northwest direction. The highway intersects with Interstate 20, entering into the city of Odessa. US 385 runs through the city, leaving it just south of the northern intersection with Loop 338.
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